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Fructose does not stimulate release of insulin.  One of insulin’s important functions is central regulation of hunger.  Fructose does not affect the hypothalamus directly or through insulin.  Fructose does not appear to dampen the sense of hunger.

Insulin release can modulate food intake by at least two mechanisms. First, insulin concentration in the central nervous system has a direct inhibitory effect on food intake. In addition, insulin may modify food intake by its effect on leptin secretion, which is mainly regulated by insulin-induced changes in glucose metabolism in fat cells. Insulin increases leptin release with a time delay of several hours. Thus, a low insulin concentration after ingestion of fructose would be associated with lower average leptin concentrations than would be seen after ingestion of glucose. Because leptin inhibits food intake, the lower leptin concentrations induced by fructose would tend to enhance food intake and thus the appetite is not suppressed. Thus this is another reason for obesity due to excessive fructose consumption.

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