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A 30-year-old female presents with burning on urination and blood in her urine. She is diagnosed with a urinary tract infection. She is prescribed an antibiotic that inhibits an enzyme that prevents extreme supercoiling of DNA. Super coiling of DNA results from unwinding at a replication fork. This enzyme breaks and rejoins DNA chains. Which of the following is the most characteristic of this enzyme?

A. Helicase

B. Single strand binding protein

C. Topo isomerase

D. DNA polymerase I

E. DNA polymerase III

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