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The most common cause of β- Thalassemia is the defect in mRNA splicing of the beta globin gene. Mutations that affect the splicing create aberrant transcripts that are degraded before they are translated. If patients inherit a single mutated gene (thalassemia minor), the disease manifests with a mild anemia. However, patients with homozygous mutations (thalassemia major) have severe transfusion-dependent anemia. Which of the following types of RNA are involved in the splicing process?

A. Ribosomal RNA (r RNA)

B. Small nuclear RNA (sn RNA)

C. Transfer RNA (t RNA)

D. Small cytoplasmic RNA (sc RNA)

E. Heterogeneous nuclear RNA (hn RNA) 

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