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Lactate is oxidized to pyruvate in a reaction catalyzed by Lactate dehydrogenase. The patients with genetic deficiency of lactate dehydrogenase present with muscle cramping and myoglobinuria after intense exercise. The sources of lactate include muscle and red blood cells. Lactate is a waste product in such cells; it is transported to liver and can be converted to glucose through pathway of gluconeogenesis. The energy requirements for conversion of lactate to glucose are:

A. 2 ATP

B. 4 ATP

C. 6 ATP

D. 8 ATP

E. 38 ATP.

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