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- A New Book of Biochemistry
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Subjective Questions- Metabolism of Nucleotides
Q.2- Describe two diseases caused by abnormal nucleotide metabolism and explain their biochemical basis.
Q.3- Outline briefly how deoxythymidylate can be synthesized from uridylate.
Q.4- Briefly describe the biochemical basis of the following (a) Lesch Nyhan syndrome (b) Orotic aciduria.
Q.5- Explain how azaserine and sulfonamides inhibit purine nucleotide synthesis?
Q.6- Describe 2 savage pathways for purines
Q.7-Describe the role of folic acid in the nucleotide biosynthesis and describe the step which is inhibited by Methotrexate, an anticancer drug.
Q.8- Describe the steps and regulation of Pyrimidine biosynthesis and highlight the site of defect for orotic aciduria.
Q.9- What are important differences between Carbamoyl phosphate synthetase 1 and II.
Q.10- Deficiency of urea cycle enzymes especially Ornithine Trans Carbamoylase leads to Orotic aciduria, explain the biochemical basis for this finding.
Q.11- Uridine and Cytidine are given as a part of treatment for orotic aciduria. What is the biochemical basis for this supplementation?
Q.12- Describe the steps of degradation of Purines and discuss the clinical significance if any of this pathway.
Q.13- What is gout? Discuss the causes, clinical manifestation and treatment of gout.
Q.14- Name the enzymes, the abnormal activities of which can cause hyperuricemia; explain the reactions catalyzed and discuss the basis for hyperuricemia in each of these conditions.
Q.15-Explain the biochemical basis of hyperuricemia in chronic alcoholism
Q.16- Explain the biochemical basis of hyperuricemia upon excessive fructose / fruit ingestion
Q.17- Explain the biochemical basis of hyperuricemia in Von-Gierke’s disease.
Q.18- Show by means of a reaction the conversion of Ribonucleotides to deoxy Ribonucleotides.
Q.19-Show the steps of conversion of IMP(Inosine mono phosphate) to AMP (Adenosine monophosphate and GMP (Guanosine mono phosphate).
Q.20 -Show by means of reaction the counter regulation in the de novo synthesis of purine nucleotides.
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