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Chapter-3 -Formation and Fate of Pyruvate

 Q.1- Discuss the fate of pyruvate under different metabolic conditions.

 Q.2- Give a brief account of Pyruvate dehydrogenase complex and explain the role of various factors and hormones in the regulation of this complex.

 Q.3–What could be the consequences of Pyruvate dehydrogenase complex (PDH) deficiency, explain  in detail about the causes, clinical manifestations and treatment of patients suffering from PDH complex deficiency?

 Q. 4- What is the cause of lactic acidosis in PDH complex deficiency?

Chapter 4- TCA Cycle/Citric acid Cycle/ Krebs cycle

 Q.1-What is TCA cycle?  Describe the steps and explain the reason that citric acid cycle can operate only in the presence of oxygen?

 Q.2-What would be the total energy yield when glucose is completely oxidized to CO2 and water?

 Q.3- Discuss the regulation of TCA cycle.


What is respiratory control of TCA cycle?

 Q.4- What is the significance of TCA Cycle?


 Discuss the amphibolic role of TCA cycle

 Q.5.- Discuss the role played by vitamins in the operation of TCA cycle

 Q6.- What are Anaplerotic reactions ?


How are citric acid cycle intermediates replenished if any are drawn off for biosynthesis?

 Q.7- Why it is said that fats burn in the flame of carbohydrates?

 Q.8 -What would be the total energy yield from complete oxidation of Acetyl coA in TCA Cycle in the presence of Malonate?

 Q.9- Enlist the inhibitors of TCA cycle and mention the mechanism of action of each of them.

Chapter 5- Gluconeogenesis

 Q.1- Justify the statement -Gluconeogenesis is not a reversal of glycolysis.


 Give a brief account of the thermodynamic barriers of gluconeogenesis.

 Q.2 – How do the substrates of gluconeogenesis gain entry in to the main pathway?

 Explain giving reactions involving each substrate.

 Q.3- “It is incorrect to say that fats can not be converted to glucose”. Comment on the 


 Q.4- What is Cori cycle or Lactic acid cycle? How does it differ from Glucose Alanine cycle? Explain how muscle may be used to supply energy in a wasting condition like anorexia nervosa.

 Q.5- Comment on the statement– ‘Glycolysis and Gluconeogenesis are reciprocally regulated’


Discuss the regulation of Gluconeogenesis.

 Q.6 – What is the cause of Alcohol induced hypoglycemia?

 Q.7- Premature and low-birth-weight babies are more susceptible to hypoglycemia, what could be the possible cause for this?

 Q.8-What is the role played by kidney in gluconeogenesis?

 Q.9-What is the biochemical basis for

 a) Hypoglycemia in-Babies of diabetic mothers

 b) Maternal  hypoglycemia  during pregnancy

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