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Subjective questions- Carbohydrate Metabolism-1(Digestion and absorption of carbohydrates and Glycolysis)
Chapter-1 Digestion and Absorption of Carbohydrates
Q.1– Give a brief account of digestion and absorption of dietary carbohydrates.
Q.2- Discuss the causes, consequences, laboratory diagnosis and treatment of lactose intolerance
Q.3- Discuss the mechanism of Glucose uptake in peripheral tissues
Q.1- In mammals, glucose is the only fuel that the brain uses under non starvation conditions and the only fuel that red blood cells can use at all. There are many carbohydrates, Why is glucose instead of some other monosaccharides such a prominent fuel?
Q.2- Justify the statement ‘Hexokinase Traps Glucose in the Cell and begins Glycolysis’.
Q.3- What are the important differences between Hexokinase and Glucokinase?
Q.4- Give a brief account of glycolysis mentioning the steps and the energy yield per molecule of glucose.
Q.5- Discuss the regulation of Glycolysis. Why is phosphofructokinase rather than hexokinase the pacemaker of glycolysis?
Q.6 – Explain the effect of increasing the concentration of each of the following metabolites on the net rate of glycolysis: (a) glucose-6-phosphate (b) fructose-1,6-bisphosphate (c) citrate.
Q.7- Discuss the formation and degradation of Fructose 2,6 bisphosphate. What is feed forward stimulation in glycolysis?
Discuss the role of Fr 2,6 bisphosphate in the regulation of glycolysis.
How is the concentration of fructose 2,6-bisphosphate appropriately controlled?
Q.8- Red blood cells have an alternate pathway for glycolysis that produces an intermediate that is essential for the function of the red blood cell. This detour bypasses an ATP generating step. Discuss this detour in terms of the intermediate that is generated and the function of red blood cells.
What is Luebering-Rapapport pathway? What is its significance?
Q.9 – Explain which metabolic intermediate(s) will accumulate when each of the following is added to cell-free extracts capable of glycolysis: (a) fluoride, which inhibits Enolase (b) an inhibitor of lactate dehydrogenase (c) an inhibitor of pyruvate kinase.
Q.10-Glucose-6-phosphate is at the cross roads of 3 metabolic pathways in liver cells. Name the pathways and discuss the metabolic conditions that determine which pathway will prevail.
Q.11- Justify the statement –“Muscle cells derive almost all of the ATP consumed during exertion from anaerobic glycolysis.”
Why is lactate, rather than pyruvate, produced by normal muscle when it is working anaerobically?
Q.12 Are substrates other than glucose used in Glycolysis?
Q.13- What is the significance of glycolysis other than energy production?
Q.14- What is the cause of haemolytic anemia in patients suffering from Pyruvate kinase deficiency?Please help "Biochemistry for Medics" by CLICKING ON THE ADVERTISEMENTS above!