Q.2- Give a diagrammatic representation of each of the followings-
i) ATP synthase complex
ii) Visual Cycle
iii) Carnitine shuttle
Mention the functional/clinical significance of each of them.
Q.3- a) Give a brief account of the role of niacin as a coenzyme, highlight the important reactions and mention the names of the enzymes requiring niacin as a coenzyme. What would be the clinical implications of its deficiency?
b) Give a brief description of the abnormalities that can lead to fatty liver formation. Support your answer by a suitable flow chart or a diagram summarizing the mechanisms involved in fatty liver formation.
Q.4-a) Enlist the important non carbohydrate precursors of Glucose and show the entry of any two of them in the main pathway of gluconeogenesis.
b) Give a detailed description of the factors that affect the enzyme activity in vivo.
Support your answer by suitable graphs or diagrams.
Q.5- Write short note on-
a) Phase 1 reactions of detoxification
b) Steps and regulation of cholesterol synthesis
c) Glucose- Alanine cycle
Q.6- Giving the biochemical defect, pathogenesis, clinical manifestations, laboratory diagnosis and possible treatment, describe the following diseases-
c) Diabetic ketoacidosis
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