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State true or false

1) Glyceraldehyde-3-phosphate dehydrogenase catalyzed step is the main step for energy yield under anaerobic conditions.

2) Succinate is the substrate for Succinate Thiokinase enzyme.

3) Glycerol kinase enzyme is absent in the adipose tissues.

4) Phosphoglycerate kinase catalyzed step yields energy by substrate level phosphorylation.

5) Diabetic ketoacidosis is a commonest complication of type 2 diabetes mellitus.

6) The plasma C- peptide level is a marker of endogenously synthesized insulin.

7) Insulin receptor has tyrosine kinase activity.

8) Acetyl co A is an ideal substrate for gluconeogenesis.

9) Insulin promotes lipolysis by stimulating hormone sensitive lipase.

10) Oral glucose tolerance test is a confirmatory test in suspected cases of diabetes mellitus.

11) Aconitase enzyme catalyzes the condensation of Acetyl co A and Oxalo acetate.

12) Enolase is inhibited by Arsenate.

13) Inherited Aldolase A deficiency and pyruvate kinase deficiency in erythrocytes cause hemolytic anemia.

14) Muscle glycogen functions to store and export glucose to maintain blood glucose between meals.

15) Glucose 6-phosphatase hydrolyzes glucose 6-phosphate in muscles, yielding glucose that is exported, leading to an increase in the blood glucose concentration.

16) Liver and kidney are the major gluconeogenic tissues.

17) Galactose and fructose are readily converted to glucose in the liver.

18) Epinephrine and nor epinephrine stimulate the release of insulin.

19) Glucose 6-phosphate dehydrogenase is an NAD+-dependent enzyme.

20) Ribose can not be synthesized in all tissues.

21) In the liver, fructose increases triacylglycerol synthesis and VLDL secretion, leading to hypertriacylglycerolemia.

22) Microalbuminuria is a measure of a nearly and reversible nephropathy.

23) A low blood glucose level is more harmful than hyperglycemia.

24) Hypoglycemia is not a diagnosis but is a biochemical sign associated with a group of diverse diseases.

25) A fall in pH stimulates phosphofructo kinase activity.

26) GLUT5, present in the small intestine, functions primarily as a fructose transporter.

27) Glycolysis is diminished and gluconeogenesis is accelerated in the fed state.

28) The formation of acetyl CoA from carbohydrates is less direct than from fat.

29) The rate of TCA cycle is reduced when the cell has a high level of ATP.

30) Two high-energy phosphate bonds are consumed in a reaction, which is catalyzed by pyruvate carboxylase.


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2 Responses to Questions From Carbohydrate Metabolism – State True or False

  • Artificial tears used in dry eye (R.A. like autiimune ) are carbohydrate in nature.
    Digoxin is Cho.
    Antibiotic as Cho.
    2-3 Bisphosphoglycerate function.
    Cytostatin -C,early kidney failure in diabetes.
    What is the benefit of Enz. Hexokinase &glucokinASE FOR DIFFERENT AFFINITY FOR SUBSTRATE GLUCOSE.

  • Well sir, i have not completely understood your question, but regarding hexokinase and glucokinase, here is the answer-
    Glucokinase has a high km (Low affinity)for Glucose , that is it requires a large amount of Glucose to achieve the half maximum velocity. This is beneficial for handling the glucose load in the fed state for maintaing the blood glucose conc. within the physiological range.On the other hand Hexoknase has a low km (High affinity) for glucose, so it can phosphorylate even a very minute concentartion of glucose which is important for maintaing the intracelllar glucose concentration. Phosphorylated glucose can enter any of the pathways depending upon the need of the cell.Hexokinase has a low V max and is also inhibited by its product so it is incapable of handling a high Glucose load, while Glucokinase although has low affinity but it is not product inhibited and has a high V max so is capable of handling a high glucose load. Mutations in the Glucokinase gene lead to Diabetes Mellitus since the glucose uptake is affected in the liver cells with the resultant hyperglycemia.
    I hope i have given the answer.
    Regrading all others
    Digoxin is a cardiag Glycoside.
    2,3 bisphosphoglycerate, a product of RL shunt is needed for unloading of oxygen to the peripheral tissues.
    Carbohydrate based antibiotics are recently been synthesized to deal with the problem of drug resistance.
    Cytostatin is antimetastatic agent , it prevents the cell adhesion to the extracellular matrix, its mechanism of action is yet not fully known but perhaps acts by inhibiting a kind of protein phosphatse 2. I shall discuss about them in any of my next posts, so far i am doing only basic revision. Thank you so much sir for showing your interest.