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Chapter-7- Uronic acid pathway
Q.1 -Discuss the steps of Uronic acid pathway and state its biological significance?
Which pathway of Glucose utilization is involved in the detoxification of Bilirubin and other foreign substances? Write the steps and elaborate on the process of detoxification of the foreign substances by the product of this pathway.
Which pathway of glucose utilization is involved in the synthesis of Ascorbic acid in plants and many organisms? What is the reason that human beings and certain animals still require Ascorbic acid in their diets?
Q.2- What is the defect in essential Pentosuria? How can this be diagnosed? What are the clinical manifestations and how is this defect treated?
A 35-year-old male was referred to the biochemical laboratory for the study of his mellituria. The urinary sugar had been discovered during hospitalization for the repair of an inguinal hernia when the patient was 20 years of age, and he was then refused operation because of”diabetes.” Numerous blood sugar analyses were reported normal. The patient was in excellent health and had no symptoms of diabetes, but was concerned about his condition .L- Xylulose was present excessively in urine.What is the probable diagnosis?
Chapter-8- Glycogen Metabolism
Q.1- Why do animals store energy as glycogen? Why not convert all excess fuel into fatty acids?
Q.2- What is Glycogenesis? Describe the steps and state under what conditions Glycogenesis would be promoted in the body?
Describe the separate roles of Glycogenin and Glycogen Synthase in glycogen synthesis. Summarize the reactions catalyzed by each enzyme.
Q.3- Explain the pathway by which Glycogen is degraded in the body.
Give a brief account of the process of Glycogenolysis. Highlight the role played by each of the participating enzymes.
Q.4- What is the role played by pyridoxal phosphate in glycogen metabolism?

Q.5- What is the cost of converting glucose 6-phosphate into glycogen and back into glucose-6-phosphate?


Q.6-Is the energy required to synthesize glycogen from glucose 6-phosphate the same as the energy required to degrade glycogen to glucose 6-phosphate?

Q.7-“The phosphoroylytic cleavage of glycogen is the key for glycogen metabolism.” Justify the statement.

Q.8- Give a brief account of the regulation of glycogen metabolism.


Discuss the regulation of Glycogen metabolism during well fed and fasting states.


What is the effect of a high carbohydrate meal upon blood glucose and the glucose in liver cells?

Q.9 How does the regulation of phosphorylase in the liver differ from phosphorylase regulation in muscle?

Q.10-What is the effect of changes in the insulin/glucagon ratio, blood glucose or epinephrine upon glycogen synthesis and glycogen degradation in the liver?

Q.11-What is the effect of insulin upon the cAMP cascade?

Q.12-What are the three major activators of phosphorylase in muscle?

Q.13- Draw a diagram and describe the reaction cascade by which cyclic AMP alters activity of the Glycogen Phosphorylase enzyme.

Q.14- How does the rise in cytosolic [Ca++]that occurs during activation of muscle contraction affect glycogen breakdown? How is this significant with regard to metabolism during muscle contraction?

Q.15- Give a brief account of the defect,clinical presentation, laboratory diagnosis and treatment of-

a) Von-Gierke’s disease
b) McArdle’s syndrome
c) Amylopectinosis
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One Response to Questions- Carbohydrate Metabolism-4 (Uronic acid pathway and Glycogen Metabolism)

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