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A 54- year-old man with Type 1 diabetes is referred to an ophthalmologist for evaluation of developing cataract. Blood chemistry results are shown below-

Fasting blood glucose   198 mg/dl

Hemoglobin A                  15 gm/dl

Hemoglobin A 1c             10% of total Hb

Urine ketones                   Positive

Urine glucose                    Positive

Which of the following enzymes is most strongly associated with ketones formation in this patient?

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