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Q.1- What is the biochemical basis for the followings in Diabetes mellitus

a) Weight loss

b) Paresthesias

c) Increased susceptibility to infections

d) Non healing ulcers

e) Blindness

f) Hypoglycemia

g) Lactic acidosis

h) Ketosis

i) Hypercholesterolemia

j) High risk for IHD

Q- 2 What is Glycated hemoglobin? What is its significance in the diagnosis of Diabetes mellitus?

Q.3- What is the cause of Hypokalemia upon insulin administration in diabetics?

Q.4.- What is Maturity onset diabetes mellitus of young (MODY)?

Q.5-What is LADA (Latent Auto immune diabetes mellitus of Adults)?

Q.6- What are the important differences between Type 1 and Type 2 diabetes mellitus?

Q.7- What is the cause of insulin resistance in type 2 diabetes mellitus?

Q.8-A 35 year- old woman reported with classical symptoms of polyuria, Polyphagia and Polydipsia. Her fasting blood glucose was 190 mg/dl. She was diagnosed with Diabetes mellitus and was started with oral hypoglycemic drugs. A week later her blood glucose was repeated and was found to be 234 mg/dl.  What could be the reason for increasing blood glucose level despite glucose lowering therapy? Which investigation should be carried out for further diagnosis?

Q.9-What is the significance of estimating c-peptide levels?

Q.10- What are diabetes prone states?

Q.11-What are the secondary causes of diabetes mellitus?

Q.12- What is the significance of detecting microalbuminuria in diabetes mellitus?

Q.13-What is the biochemical basis for impaired glucose uptake in skeletal muscles and adipose tissue in diabetes mellitus?

Q.14- What is the biochemical basis for complications in diabetes mellitus?

Q.15- What are the acute complications of diabetes mellitus?

Q.16-What are late onsets or chronic complications of diabetes mellitus?

Q.17-What is meant by “Advanced glycation end products”?

Q.18- What are the metabolic alterations brought about in the absence of insulin in diabetes mellitus?

Q.19- Enumerate the different tests carried out for the diagnosis of diabetes mellitus?

Q.20 Suggest a healthy diet for a diabetic patient? What is the role of dietary fiber?

Q.21- What is the treatment for diabetic ketoacidosis?

Q.22- What should be the fasting and post load blood glucose values for a person to be declared as  having impaired glucose tolerance?

Q.23- What are the indication for carrying out oral glucose tolerance test ?

Q.24 -What is the criteria for the laboratory diagnosis of diabetes mellitus after oral glucose tolerance test?

Q.25- What is the significance of serum fructosamine estimation in diabetes mellitus?

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