Main Menu

Tangier disease is a disease of cholesterol transport. The first case was identified in a patient who lived on the island of Tangier and who had characteristic orange-colored tonsils, a very low HDL level, and an enlarged liver and spleen. Due to a mutation in the transport protein the cholesterol cannot properly exit the cell to bind to apo A (that forms HDL). This results in a very low HDL levels.

Cholesterol obtained by HDL from cell membranes is converted to cholesterol esters.

Which of the following enzymes catalyzes the esterification of cholesterol?

A. HMG Co A reductase

B. Lecithin: cholesterol acyl transferase

C. 7-Alpha hydroxylase

D. Acyl: Cholesterol acyl transferase

E. Thiophorase

Check the details at

Please help "Biochemistry for Medics" by CLICKING ON THE ADVERTISEMENTS above!