Tangier disease is a disease of cholesterol transport. The first case was identified in a patient who lived on the island of Tangier and who had characteristic orange-colored tonsils, a very low HDL level, and an enlarged liver and spleen. Due to a mutation in the transport protein the cholesterol cannot properly exit the cell to bind to apo A (that forms HDL). This results in a very low HDL levels.
Cholesterol obtained by HDL from cell membranes is converted to cholesterol esters.
Which of the following enzymes catalyzes the esterification of cholesterol?
A. HMG Co A reductase
B. Lecithin: cholesterol acyl transferase
C. 7-Alpha hydroxylase
D. Acyl: Cholesterol acyl transferase
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