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Changes in the pH can alter these changes, so that the reaction proceeds at a slower rate. If the pH is too high or too low, the enzyme can also undergo denaturation. Which of the following statements is true of denaturation?

A. The enzyme loses its capacity to hold the substrate

B. The 3 D structure of the enzyme is disrupted

C. The active site is lost

D. The enzyme fails to bind the coenzyme

E. All of the above.

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