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Subjective Questions

Q. 1-Outline the process of detoxification of following compounds

i) Aspirin            ii) Digitalis            iii)  Polycyclic aromatic hydrocarbons

Q.2- “The complete detoxification of xenobiotics requires the concerted action of enzymes in Phase 1 and Phase 2 reactions, justify the statement giving at least one example

Q.3- Discuss in detail about the detoxification of Bilirubin and elaborate the clinical significance associated with these reactions.

Q.4-A 4- year-old – child accidently ingested Methanol and was rushed to hospital.  He was given Ethanol as an antidote and was kept under observation. What is the basis of using ethanol? Explain the steps of detoxification by giving the relevant reactions.

Q.5- Give a brief account of cytochrome P 450 enzyme system. Discuss the important characteristics.

Q.6-What is meant by entoxification of xenobiotics? Give examples in support of your answer.

Q.7- Give a detailed account of phase 1 reactions of detoxification, suggest examples for each set of reactions.

Q.8- Discuss the role of glycine as a conjugating agent. What is the significance of this reaction?

Q.9- Give an account of transmethylation reactions undertaken for the detoxification of xenobiotics.

Q.10-Give a brief description of the role of amino acids in the detoxification of foreign compounds, discuss the significance of each reaction.

Q.11- Give a detailed account of phase II reactions of detoxification. Give examples for each category of reactions.

Q.12-  What  are slow and fast acetylators ? Explain in relation to acetylation of Isoniazid.

Q.13- What are the effects of xenobiotics? Discuss the role of glutathione as a defense peptide from the effect of peptides.

Q.15- Discuss the role of BAL in the detoxification of toxic metals.

Q.16- Outline the step of detoxification of cyanide, what are the clinical implications of cyanide toxicity?

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