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A 34-year-old homosexual man has recently been diagnosed with HIV (human immunodeficiency virus) infection. His CD4+ T-cell count has dramatically decreased, and he has a high viral load. He is referred to an infectious disease clinic where he has been prescribed with a nucleoside analog. The nucleoside analogs inhibit DNA synthesis. Which of the following chemical groups essentially required for DNA polymerization is absent in the nucleoside analogs?

A. 5′ Phosphate

B. 3′ Hydroxyl

C. 2′ Methyl

D. 3′-Phosphate

E. 5′ Hydroxyl.

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